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Combining tools to understand collagen remodeling

Dr. Leila Mostaço-Guidolin

Assistant Professor, Department of Systems and Computer Engineering, Carleton University

September 8, 2020 15:30 - 16:30

This is an online event that will be held over Zoom. The details on how to join the event will be available once you register.

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abstract

Imaging modalities capable of characterizing cells and tissues help us to understand the progression of diseases, detecting lesions with a high risk for acute events, and even providing information that can be applied towards the development of new drugs and therapies. Multimodal nonlinear optical microscopy (NLOM) is a powerful tool that can be used for label-free visualization of key extracellular molecules, such as collagen and elastin, which are involved in detrimental remodelling of several tissues. In this presentation, I will share a story of how texture analysis can help us to track changes happening inside of the airways due to asthma. I will also show how 3D-bioprinting can be used in fundamental research, as a tool to construct simplified models of complex biological systems, such as the extracellular matrix.

biography

Dr. Mostaço-Guidolin obtained her doctorate from the Biomedical Engineering program at the University of Manitoba, working in a close collaboration with the National Research Council in Winnipeg. She developed image analysis methods to characterize cardiovascular diseases. After completing her graduate work, she moved to Vancouver to undertake a postdoctoral position at the University of British Columbia, at the Center for Heart and Lung Innovation, working on the application of imaging modalities for respiratory research and the development of 3D in-vitro models. At Carleton University, she will be establishing a 3D-bioprinting/imaging lab to study changes associated with fibrosis and extracellular matrix remodelling in diseases.